The GCB Bank liberty house branch in Accra Central Business District has been gutted by a fire.
The fire is believed to have started around 11 am on Saturday, according to the Fire Service.
But some eyewitnesses are disputing the the reports of the Fire Service saying the fire started hours earlier.
Fire Service personnel have been on the scene for about 45 minutes and are yet to ascertain the cause of the fire on the first floor of the seven-story building.
According to the fire service, the affected floor contained stationery.
There are about six fire trucks at the scene and fire service personnel have been able to keep the fire from spreading.
Police have also had to barricade some roads leading to the area causing heavy traffic.
There are no reports of any casualties so far.